Multi-omics in mesial temporal lobe epilepsy with hippocampal sclerosis: Clues into the underlying mechanisms leading to disease

Mesial temporal lobe epilepsy (MTLE) is one of the most common types focal in adult population. MTLE frequently associated with a specific histopathological lesion medial structures, namely hippocampal sclerosis (HS). A significant proportion patients MTLE+HS have severe epilepsy, which often resistant to clinical treatment. For these patients, surgical resection epileptogenic can be performed. Our understanding underlying mechanisms leading has improved significantly over past few decades. In this review, we aim present and discuss recent findings regarding genetic determinants MTLE+HS. Furthermore, will address studies about transcriptomics, proteomics, metabolomics, epigenomic signatures tissue that surgically removed from refractory animal models disorder. We expect provide an overview critical discussion findings, limitations, new approaches, future directions for multi-omics